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It is thought to be due to its disruption of the regulation of serotonin, a brain chemical believed to play a role in mood and memory. However studies suggest this effect reverses after a 2-3 month abstinence. After several severe collapses at parties, Mr A decided to stop taking ecstasy. Conclusions from this are often flawed because few, if any, drugs users use ecstasy in isolation. His long- term memory was fine but he could not remember day to day things - the time, the day, what was in his supermarket trolley said Dr Kouimtsidis. "This is obviously an extreme case so we should not blow any observations out of proportion says Dr Kouimtsidis. Doctors from London University have revealed details of what they believe is the largest amount of ecstasy ever consumed by a single person. For 10 years, mdma has been suspected of causing these kinds of effects in heavy users.